Hesperidin Displays Relevant Role in the Nutrigenomic Effect of Orange Juice on Blood Leukocytes in Human Volunteers: A Randomized Controlled Cross-Over Study
Identifieur interne : 000095 ( France/Analysis ); précédent : 000094; suivant : 000096Hesperidin Displays Relevant Role in the Nutrigenomic Effect of Orange Juice on Blood Leukocytes in Human Volunteers: A Randomized Controlled Cross-Over Study
Auteurs : Dragan Milenkovic [France] ; Christiane Deval [France] ; Claude Dubray [France] ; Andrzej Mazur [France] ; Christine Morand [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2011.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Hesperidin.
- analysis : Beverages.
- chemistry : Citrus sinensis.
- drug effects : Leukocytes, Transcriptome.
- metabolism : Leukocytes.
- Aged, Cross-Over Studies, Humans, Male, Middle Aged, Nutrigenomics, Oligonucleotide Array Sequence Analysis, Time Factors.
Abstract
We previously showed, in healthy, middle-aged, moderately overweight men, that orange juice decreases diastolic blood pressure and significantly improves postprandial microvascular endothelial reactivity and that hesperidin could be causally linked to the observed beneficial effect of orange juice. The objective was to determine the effect of chronic consumption of orange juice on the gene expression profile of leukocytes in healthy volunteers and to assess to what extent hesperidin is involved in the effect of orange juice.
Volunteers were included in a randomized, controlled, crossover study. Throughout three 4-week periods, volunteers consumed daily: 500 ml orange juice, 500 ml control drink plus hesperidin or 500 ml control drink and placebo. Blood samplings were performed on 10 overnight-fasted subjects after the 4-week treatment period. Global gene expression profiles were determined using human whole genome cDNA microarrays. Both orange juice and hesperidin consumption significantly affected leukocyte gene expression. Orange juice consumption induced changes in expression of, 3,422 genes, while hesperidin intake modulated the expression of 1,819 genes. Between the orange juice and hesperidin consumption groups, 1,582 regulated genes were in common. Many of these genes are implicated in chemotaxis, adhesion, infiltration and lipid transport, which is suggestive of lower recruitment and infiltration of circulating cells to vascular wall and lower lipid accumulation.
This study shows that regular consumption of orange juice for 4 weeks alters leukocyte gene expression to an anti-inflammatory and anti-atherogenic profile, and hesperidin displays a relevant role in the genomic effect of this beverage.
ClinicalTrials.gov
Url:
DOI: 10.1371/journal.pone.0026669
PubMed: 22110589
PubMed Central: 3217928
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001226
- to stream Pmc, to step Curation: 001225
- to stream Pmc, to step Checkpoint: 000E50
- to stream PubMed, to step Corpus: 000786
- to stream PubMed, to step Curation: 000786
- to stream PubMed, to step Checkpoint: 000786
- to stream Ncbi, to step Merge: 000E50
- to stream Ncbi, to step Curation: 000E50
- to stream Ncbi, to step Checkpoint: 000E50
- to stream Main, to step Merge: 001746
- to stream Main, to step Curation: 001723
- to stream Main, to step Exploration: 001723
- to stream France, to step Extraction: 000095
Links to Exploration step
PMC:3217928Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hesperidin Displays Relevant Role in the Nutrigenomic Effect of Orange Juice on Blood Leukocytes in Human Volunteers: A Randomized Controlled Cross-Over Study</title><author><name sortKey="Milenkovic, Dragan" sort="Milenkovic, Dragan" uniqKey="Milenkovic D" first="Dragan" last="Milenkovic">Dragan Milenkovic</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Deval, Christiane" sort="Deval, Christiane" uniqKey="Deval C" first="Christiane" last="Deval">Christiane Deval</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Dubray, Claude" sort="Dubray, Claude" uniqKey="Dubray C" first="Claude" last="Dubray">Claude Dubray</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Inserm, CIC 501, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CIC 501, Clermont-Ferrand</wicri:regionArea><placeName><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22110589</idno><idno type="pmc">3217928</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217928</idno><idno type="RBID">PMC:3217928</idno><idno type="doi">10.1371/journal.pone.0026669</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001226</idno><idno type="wicri:Area/Pmc/Curation">001225</idno><idno type="wicri:Area/Pmc/Checkpoint">000E50</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000786</idno><idno type="wicri:Area/PubMed/Curation">000786</idno><idno type="wicri:Area/PubMed/Checkpoint">000786</idno><idno type="wicri:Area/Ncbi/Merge">000E50</idno><idno type="wicri:Area/Ncbi/Curation">000E50</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E50</idno><idno type="wicri:Area/Main/Merge">001746</idno><idno type="wicri:Area/Main/Curation">001723</idno><idno type="wicri:Area/Main/Exploration">001723</idno><idno type="wicri:Area/France/Extraction">000095</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hesperidin Displays Relevant Role in the Nutrigenomic Effect of Orange Juice on Blood Leukocytes in Human Volunteers: A Randomized Controlled Cross-Over Study</title><author><name sortKey="Milenkovic, Dragan" sort="Milenkovic, Dragan" uniqKey="Milenkovic D" first="Dragan" last="Milenkovic">Dragan Milenkovic</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Deval, Christiane" sort="Deval, Christiane" uniqKey="Deval C" first="Christiane" last="Deval">Christiane Deval</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Dubray, Claude" sort="Dubray, Claude" uniqKey="Dubray C" first="Claude" last="Dubray">Claude Dubray</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Inserm, CIC 501, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, CIC 501, Clermont-Ferrand</wicri:regionArea><placeName><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INRA, UMR 1019, UNH, CRNH Auvergne, Clermont-Ferrand, Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, Clermont-Ferrand</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Champagne-Ardenne</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Beverages (analysis)</term><term>Citrus sinensis (chemistry)</term><term>Cross-Over Studies</term><term>Hesperidin (pharmacology)</term><term>Humans</term><term>Leukocytes (drug effects)</term><term>Leukocytes (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Nutrigenomics</term><term>Oligonucleotide Array Sequence Analysis</term><term>Time Factors</term><term>Transcriptome (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Hesperidin</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Beverages</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Leukocytes</term><term>Transcriptome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cross-Over Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nutrigenomics</term><term>Oligonucleotide Array Sequence Analysis</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>We previously showed, in healthy, middle-aged, moderately overweight men, that orange juice decreases diastolic blood pressure and significantly improves postprandial microvascular endothelial reactivity and that hesperidin could be causally linked to the observed beneficial effect of orange juice. The objective was to determine the effect of chronic consumption of orange juice on the gene expression profile of leukocytes in healthy volunteers and to assess to what extent hesperidin is involved in the effect of orange juice.</p></sec><sec><title>Methodology/Principal Findings</title><p>Volunteers were included in a randomized, controlled, crossover study. Throughout three 4-week periods, volunteers consumed daily: 500 ml orange juice, 500 ml control drink plus hesperidin or 500 ml control drink and placebo. Blood samplings were performed on 10 overnight-fasted subjects after the 4-week treatment period. Global gene expression profiles were determined using human whole genome cDNA microarrays. Both orange juice and hesperidin consumption significantly affected leukocyte gene expression. Orange juice consumption induced changes in expression of, 3,422 genes, while hesperidin intake modulated the expression of 1,819 genes. Between the orange juice and hesperidin consumption groups, 1,582 regulated genes were in common. Many of these genes are implicated in chemotaxis, adhesion, infiltration and lipid transport, which is suggestive of lower recruitment and infiltration of circulating cells to vascular wall and lower lipid accumulation.</p></sec><sec><title>Conclusions</title><p>This study shows that regular consumption of orange juice for 4 weeks alters leukocyte gene expression to an anti-inflammatory and anti-atherogenic profile, and hesperidin displays a relevant role in the genomic effect of this beverage.</p></sec><sec><title>Trial Registration</title><p>ClinicalTrials.gov <ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov/ct2/results?term=NCT+00983086">NCT 00983086</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morand, C" uniqKey="Morand C">C Morand</name></author><author><name sortKey="Dubray, C" uniqKey="Dubray C">C Dubray</name></author><author><name sortKey="Milenkovic, D" uniqKey="Milenkovic D">D Milenkovic</name></author><author><name sortKey="Lioger, D" uniqKey="Lioger D">D Lioger</name></author><author><name sortKey="Martin, Jf" uniqKey="Martin J">JF Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mink, Pj" uniqKey="Mink P">PJ Mink</name></author><author><name sortKey="Scrafford, Cg" uniqKey="Scrafford C">CG Scrafford</name></author><author><name sortKey="Barraj, Lm" uniqKey="Barraj L">LM Barraj</name></author><author><name sortKey="Harnack, L" uniqKey="Harnack L">L Harnack</name></author><author><name sortKey="Hong, Cp" uniqKey="Hong C">CP Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guarnieri, S" uniqKey="Guarnieri S">S Guarnieri</name></author><author><name sortKey="Riso, P" uniqKey="Riso P">P Riso</name></author><author><name sortKey="Porrini, M" uniqKey="Porrini M">M Porrini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ghanim, H" uniqKey="Ghanim H">H Ghanim</name></author><author><name sortKey="Sia, Cl" uniqKey="Sia C">CL Sia</name></author><author><name sortKey="Upadhyay, M" uniqKey="Upadhyay M">M Upadhyay</name></author><author><name sortKey="Korzeniewski, K" uniqKey="Korzeniewski K">K Korzeniewski</name></author><author><name sortKey="Viswanathan, P" uniqKey="Viswanathan P">P Viswanathan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schroeter, H" uniqKey="Schroeter H">H Schroeter</name></author><author><name sortKey="Heiss, C" uniqKey="Heiss C">C Heiss</name></author><author><name sortKey="Balzer, J" uniqKey="Balzer J">J Balzer</name></author><author><name sortKey="Kleinbongard, P" uniqKey="Kleinbongard P">P Kleinbongard</name></author><author><name sortKey="Keen, Cl" uniqKey="Keen C">CL Keen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Widlansky, Me" uniqKey="Widlansky M">ME Widlansky</name></author><author><name sortKey="Duffy, Sj" uniqKey="Duffy S">SJ Duffy</name></author><author><name sortKey="Hamburg, Nm" uniqKey="Hamburg N">NM Hamburg</name></author><author><name sortKey="Gokce, N" uniqKey="Gokce N">N Gokce</name></author><author><name sortKey="Warden, Ba" uniqKey="Warden B">BA Warden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Auclair, S" uniqKey="Auclair S">S Auclair</name></author><author><name sortKey="Milenkovic, D" uniqKey="Milenkovic D">D Milenkovic</name></author><author><name sortKey="Besson, C" uniqKey="Besson C">C Besson</name></author><author><name sortKey="Chauvet, S" uniqKey="Chauvet S">S Chauvet</name></author><author><name sortKey="Gueux, E" uniqKey="Gueux E">E Gueux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ludwig, A" uniqKey="Ludwig A">A Ludwig</name></author><author><name sortKey="Lorenz, M" uniqKey="Lorenz M">M Lorenz</name></author><author><name sortKey="Grimbo, N" uniqKey="Grimbo N">N Grimbo</name></author><author><name sortKey="Steinle, F" uniqKey="Steinle F">F Steinle</name></author><author><name sortKey="Meiners, S" uniqKey="Meiners S">S Meiners</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vafeiadou, K" uniqKey="Vafeiadou K">K Vafeiadou</name></author><author><name sortKey="Vauzour, D" uniqKey="Vauzour D">D Vauzour</name></author><author><name sortKey="Lee, Hy" uniqKey="Lee H">HY Lee</name></author><author><name sortKey="Rodriguez Mateos, A" uniqKey="Rodriguez Mateos A">A Rodriguez-Mateos</name></author><author><name sortKey="Williams, Rj" uniqKey="Williams R">RJ Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Conesa, Mt" uniqKey="Garcia Conesa M">MT Garcia-Conesa</name></author><author><name sortKey="Tribolo, S" uniqKey="Tribolo S">S Tribolo</name></author><author><name sortKey="Guyot, S" uniqKey="Guyot S">S Guyot</name></author><author><name sortKey="Tomas Barberan, Fa" uniqKey="Tomas Barberan F">FA Tomas-Barberan</name></author><author><name sortKey="Kroon, Pa" uniqKey="Kroon P">PA Kroon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Boer, Vc" uniqKey="De Boer V">VC de Boer</name></author><author><name sortKey="Van Schothorst, Em" uniqKey="Van Schothorst E">EM van Schothorst</name></author><author><name sortKey="Dihal, Aa" uniqKey="Dihal A">AA Dihal</name></author><author><name sortKey="Van Der Woude, H" uniqKey="Van Der Woude H">H van der Woude</name></author><author><name sortKey="Arts, Ic" uniqKey="Arts I">IC Arts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spencer, Jp" uniqKey="Spencer J">JP Spencer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Camargo, A" uniqKey="Camargo A">A Camargo</name></author><author><name sortKey="Ruano, J" uniqKey="Ruano J">J Ruano</name></author><author><name sortKey="Fernandez, Jm" uniqKey="Fernandez J">JM Fernandez</name></author><author><name sortKey="Parnell, Ld" uniqKey="Parnell L">LD Parnell</name></author><author><name sortKey="Jimenez, A" uniqKey="Jimenez A">A Jimenez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chanet, A" uniqKey="Chanet A">A Chanet</name></author><author><name sortKey="Milenkovic, D" uniqKey="Milenkovic D">D Milenkovic</name></author><author><name sortKey="Deval, C" uniqKey="Deval C">C Deval</name></author><author><name sortKey="Potier, M" uniqKey="Potier M">M Potier</name></author><author><name sortKey="Constans, J" uniqKey="Constans J">J Constans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Erk, Mj" uniqKey="Van Erk M">MJ van Erk</name></author><author><name sortKey="Blom, Wa" uniqKey="Blom W">WA Blom</name></author><author><name sortKey="Van Ommen, B" uniqKey="Van Ommen B">B van Ommen</name></author><author><name sortKey="Hendriks, Hf" uniqKey="Hendriks H">HF Hendriks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouwens, M" uniqKey="Bouwens M">M Bouwens</name></author><author><name sortKey="Grootte Bromhaar, M" uniqKey="Grootte Bromhaar M">M Grootte Bromhaar</name></author><author><name sortKey="Jansen, J" uniqKey="Jansen J">J Jansen</name></author><author><name sortKey="Muller, M" uniqKey="Muller M">M Muller</name></author><author><name sortKey="Afman, La" uniqKey="Afman L">LA Afman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ardigo, D" uniqKey="Ardigo D">D Ardigo</name></author><author><name sortKey="Gaillard, Ca" uniqKey="Gaillard C">CA Gaillard</name></author><author><name sortKey="Braam, B" uniqKey="Braam B">B Braam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boomgaarden, I" uniqKey="Boomgaarden I">I Boomgaarden</name></author><author><name sortKey="Egert, S" uniqKey="Egert S">S Egert</name></author><author><name sortKey="Rimbach, G" uniqKey="Rimbach G">G Rimbach</name></author><author><name sortKey="Wolffram, S" uniqKey="Wolffram S">S Wolffram</name></author><author><name sortKey="Muller, Mj" uniqKey="Muller M">MJ Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouwens, M" uniqKey="Bouwens M">M Bouwens</name></author><author><name sortKey="Afman, La" uniqKey="Afman L">LA Afman</name></author><author><name sortKey="Muller, M" uniqKey="Muller M">M Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beissbarth, T" uniqKey="Beissbarth T">T Beissbarth</name></author><author><name sortKey="Speed, Tp" uniqKey="Speed T">TP Speed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, C" uniqKey="Weber C">C Weber</name></author><author><name sortKey="Schober, A" uniqKey="Schober A">A Schober</name></author><author><name sortKey="Zernecke, A" uniqKey="Zernecke A">A Zernecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Bw" uniqKey="Wong B">BW Wong</name></author><author><name sortKey="Wong, D" uniqKey="Wong D">D Wong</name></author><author><name sortKey="Mcmanus, Bm" uniqKey="Mcmanus B">BM McManus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Combadiere, C" uniqKey="Combadiere C">C Combadiere</name></author><author><name sortKey="Potteaux, S" uniqKey="Potteaux S">S Potteaux</name></author><author><name sortKey="Rodero, M" uniqKey="Rodero M">M Rodero</name></author><author><name sortKey="Simon, T" uniqKey="Simon T">T Simon</name></author><author><name sortKey="Pezard, A" uniqKey="Pezard A">A Pezard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stubbs, Ve" uniqKey="Stubbs V">VE Stubbs</name></author><author><name sortKey="Power, C" uniqKey="Power C">C Power</name></author><author><name sortKey="Patel, Kd" uniqKey="Patel K">KD Patel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoogeveen, Rc" uniqKey="Hoogeveen R">RC Hoogeveen</name></author><author><name sortKey="Morrison, A" uniqKey="Morrison A">A Morrison</name></author><author><name sortKey="Boerwinkle, E" uniqKey="Boerwinkle E">E Boerwinkle</name></author><author><name sortKey="Miles, Js" uniqKey="Miles J">JS Miles</name></author><author><name sortKey="Rhodes, Ce" uniqKey="Rhodes C">CE Rhodes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ni, W" uniqKey="Ni W">W Ni</name></author><author><name sortKey="Egashira, K" uniqKey="Egashira K">K Egashira</name></author><author><name sortKey="Kitamoto, S" uniqKey="Kitamoto S">S Kitamoto</name></author><author><name sortKey="Kataoka, C" uniqKey="Kataoka C">C Kataoka</name></author><author><name sortKey="Koyanagi, M" uniqKey="Koyanagi M">M Koyanagi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vazquez Agell, M" uniqKey="Vazquez Agell M">M Vazquez-Agell</name></author><author><name sortKey="Sacanella, E" uniqKey="Sacanella E">E Sacanella</name></author><author><name sortKey="Tobias, E" uniqKey="Tobias E">E Tobias</name></author><author><name sortKey="Monagas, M" uniqKey="Monagas M">M Monagas</name></author><author><name sortKey="Antunez, E" uniqKey="Antunez E">E Antunez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Damas, Jk" uniqKey="Damas J">JK Damas</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C Smith</name></author><author><name sortKey="Oie, E" uniqKey="Oie E">E Oie</name></author><author><name sortKey="Fevang, B" uniqKey="Fevang B">B Fevang</name></author><author><name sortKey="Halvorsen, B" uniqKey="Halvorsen B">B Halvorsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Apostolakis, S" uniqKey="Apostolakis S">S Apostolakis</name></author><author><name sortKey="Papadakis, Eg" uniqKey="Papadakis E">EG Papadakis</name></author><author><name sortKey="Krambovitis, E" uniqKey="Krambovitis E">E Krambovitis</name></author><author><name sortKey="Spandidos, Da" uniqKey="Spandidos D">DA Spandidos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hishikawa, K" uniqKey="Hishikawa K">K Hishikawa</name></author><author><name sortKey="Nakaki, T" uniqKey="Nakaki T">T Nakaki</name></author><author><name sortKey="Fujita, T" uniqKey="Fujita T">T Fujita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name></author><author><name sortKey="Wu, C" uniqKey="Wu C">C Wu</name></author><author><name sortKey="Zhu, B" uniqKey="Zhu B">B Zhu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dopheide, Jf" uniqKey="Dopheide J">JF Dopheide</name></author><author><name sortKey="Sester, U" uniqKey="Sester U">U Sester</name></author><author><name sortKey="Schlitt, A" uniqKey="Schlitt A">A Schlitt</name></author><author><name sortKey="Horstick, G" uniqKey="Horstick G">G Horstick</name></author><author><name sortKey="Rupprecht, Hj" uniqKey="Rupprecht H">HJ Rupprecht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niu, H" uniqKey="Niu H">H Niu</name></author><author><name sortKey="Cattoretti, G" uniqKey="Cattoretti G">G Cattoretti</name></author><author><name sortKey="Dalla Favera, R" uniqKey="Dalla Favera R">R Dalla-Favera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skubitz, Km" uniqKey="Skubitz K">KM Skubitz</name></author><author><name sortKey="Skubitz, Ap" uniqKey="Skubitz A">AP Skubitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name></author><author><name sortKey="Gower, Rm" uniqKey="Gower R">RM Gower</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Perrard, Xy" uniqKey="Perrard X">XY Perrard</name></author><author><name sortKey="Ma, R" uniqKey="Ma R">R Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nahmias, Y" uniqKey="Nahmias Y">Y Nahmias</name></author><author><name sortKey="Goldwasser, J" uniqKey="Goldwasser J">J Goldwasser</name></author><author><name sortKey="Casali, M" uniqKey="Casali M">M Casali</name></author><author><name sortKey="Van Poll, D" uniqKey="Van Poll D">D van Poll</name></author><author><name sortKey="Wakita, T" uniqKey="Wakita T">T Wakita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pennings, M" uniqKey="Pennings M">M Pennings</name></author><author><name sortKey="Meurs, I" uniqKey="Meurs I">I Meurs</name></author><author><name sortKey="Ye, D" uniqKey="Ye D">D Ye</name></author><author><name sortKey="Out, R" uniqKey="Out R">R Out</name></author><author><name sortKey="Hoekstra, M" uniqKey="Hoekstra M">M Hoekstra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oram, Jf" uniqKey="Oram J">JF Oram</name></author><author><name sortKey="Vaughan, Am" uniqKey="Vaughan A">AM Vaughan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manach, C" uniqKey="Manach C">C Manach</name></author><author><name sortKey="Williamson, G" uniqKey="Williamson G">G Williamson</name></author><author><name sortKey="Morand, C" uniqKey="Morand C">C Morand</name></author><author><name sortKey="Scalbert, A" uniqKey="Scalbert A">A Scalbert</name></author><author><name sortKey="Remesy, C" uniqKey="Remesy C">C Remesy</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Champagne-Ardenne</li><li>Grand Est</li></region><settlement><li>Clermont-Ferrand</li></settlement></list><tree><country name="France"><region name="Grand Est"><name sortKey="Milenkovic, Dragan" sort="Milenkovic, Dragan" uniqKey="Milenkovic D" first="Dragan" last="Milenkovic">Dragan Milenkovic</name></region><name sortKey="Deval, Christiane" sort="Deval, Christiane" uniqKey="Deval C" first="Christiane" last="Deval">Christiane Deval</name><name sortKey="Dubray, Claude" sort="Dubray, Claude" uniqKey="Dubray C" first="Claude" last="Dubray">Claude Dubray</name><name sortKey="Mazur, Andrzej" sort="Mazur, Andrzej" uniqKey="Mazur A" first="Andrzej" last="Mazur">Andrzej Mazur</name><name sortKey="Morand, Christine" sort="Morand, Christine" uniqKey="Morand C" first="Christine" last="Morand">Christine Morand</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000095 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000095 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= OrangerV1
|flux= France
|étape= Analysis
|type= RBID
|clé= PMC:3217928
|texte= Hesperidin Displays Relevant Role in the Nutrigenomic Effect of Orange Juice on Blood Leukocytes in Human Volunteers: A Randomized Controlled Cross-Over Study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i -Sk "pubmed:22110589" \
| HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a OrangerV1
| This area was generated with Dilib version V0.6.25. |  |